AUTHOR'S NAME: ANTONELLA FIORAVANTI

New evidence on the mechanisms of action of Balneotherapy

ANTONELLA FIORAVANTI

Rheumatologist Siena (Italy); Vice-President of ISMH President of OMTh; 


New evidence on the mechanisms of action of balneotherapy remains a debated and complex topic, due to limited knowledge and the great heterogeneity of mineral waters and thermal muds.
Three main questions guide this reflection:
Why is it so difficult to evaluate the mechanisms of action of balneotherapy?
How can we study them?
What do we know today thanks to research?
The difficulty arises from the complex composition of waters and muds – with organic, inorganic, and microbiological components – and from their great variability worldwide. The therapeutic effects are probably the result of a combination of non-specific mechanisms (related to mechanical and thermal stimuli) and specific mechanisms (linked to chemical and biological constituents).
Studies can be preclinical (on cell cultures or animal models) or clinical in humans. Preclinical studies have the advantage of isolating individual effects, but they do not always faithfully reproduce real-life conditions.
Available evidence shows that balneotherapy exerts several effects:
Analgesic, also explained by the “Gate Control” theory of pain.
Muscle relaxant and neuroendocrine, with a reduction in distress and salivary cortisol.
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Anti-inflammatory, through cytokine modulation, activation of heat shock proteins, and increased IL-10 production.

Immunomodulatory, improving the function of monocytes and neutrophils and potentially reducing susceptibility to infections.

Antioxidant, documented by both in vitro and in vivo studies.ì

Chondroprotective, in animal models of osteoarthritis, also thanks to H₂S donors.

Regulation of adipokines, although results remain inconsistent.

Epigenetic, influencing microRNAs involved in cartilage metabolism and osteoarthritis pathogenesis.

Modulation of the microbiota, with anti-inflammatory and regenerative effects observed in preclinical and clinical studies, including in patients with psoriasis.

However, some issues remain unresolved, such as mineral absorption through the skin, identification of the essential elements, and determining the most appropriate type of water or mud for each pathology.

In conclusion, research over the past years confirms that balneotherapy possesses analgesic, anti-inflammatory, antioxidant, immunomodulatory, and chondroprotective properties, but further studies are needed to fully understand the mechanisms involved and to identify the best therapeutic applications for different diseases.

CURRICULUM VITAE: 

ANTONELLA FIORAVANTI

Personal Information
• Full name: Antonella Fioravanti
• Address: Via 24 Maggio 25, 53100 Siena (ITALY)
• Phone: +39 349 5533262
• Email: fioravanti7@virgilio.it
• Nationality: Italian
• Date of birth: October 22, 1953
• Gender: Female
Work Experience
From 1989 until February 2023, she held the position of First Level Manager at the Complex Operational Unit of Rheumatology at the “Le Scotte” Polyclinic in Siena. From 2004 to February 2023, she was also in charge of a Highly Specialized role in the diagnosis and treatment of degenerative rheumatic diseases at the Azienda Ospedaliera Universitaria Senese.
She carried out clinical assistance and both clinical and basic research in rheumatology and medical hydrology. In particular, she focused on the evaluation of chondrocyte cultures to investigate new pathogenetic mechanisms and therapeutic approaches in osteoarthritis and other diseases involving joint cartilage damage. More recently, she conducted studies on the role of microRNAs in the pathogenesis of osteoarthritis.
Her key areas of interest include clinical research on osteoarthritis and the use of balneotherapy in various rheumatic diseases.
Education and Qualifications
• Scientific High School Diploma with honors (1972) – Scientific High School “Paolo Ruffini” of Viterbo (Acquapendente campus)
• Degree in Medicine and Surgery – University of Siena (October 27, 1980), summa cum laude (110/110 with honors)
• Postgraduate Degree in Endocrinology – University of Florence (1986)
• Postgraduate Degree in Rheumatology – University of Siena (1991)
• PhD in Experimental Rheumatology – University of Siena (1987)
Professional Competencies
• Fields of expertise: Rheumatology, Medical Hydrology
• Languages:
o French: Good (comprehension, speaking, writing)
o English: Good (comprehension, speaking, writing)
Personal Skills
• Social skills: Strong interpersonal and teamwork abilities
• Organizational skills: Coordination of clinical and laboratory research groups
• Technical skills: Advanced experience in laboratory techniques related to rheumatology
• Computer skills: Good proficiency with digital tools
Scientific and Professional Activities
• Lecturer at the Postgraduate Schools of Rheumatology and Internal Medicine
• Member of the Italian Society of Rheumatology (SIR) since 1982; Vice President of the Tuscany Section
• President of the Tuscany Section of the Italian League Against Rheumatic Diseases (LIMAR) from 2000 to 2004
• Member of the Scientific Board of ISMH (International Society of Medical Hydrology) since 2006
• Vice President and Scientific Director of ISMH since 2014
• President of OMTh since 2020
• Author of 275 scientific articles published in international journals
• Co-author of 15 books on rheumatic diseases and balneology
• H-index: 39
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